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What the research says

Hydrogen Water, Inflammation and Oxidative Stress

This is where hydrogen research started, and where most of the theory still sits.

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  • Studies cited
  • Plain English
  • No hype
Close-up of tiny bubbles rising in a glass of water, Albuquerque skyline and Sandia Mountains blurred behind
Tiny bubbles in fresh water.

Where it started

A 2007 study in Nature Medicine found that hydrogen gas reduced the most damaging oxygen radicals in cells and protected rat brains from injury. That paper launched hundreds of follow-up studies, most in animals and cells.

Human studies

  • Healthy adults (Sim, 2020): 38 people drank 1.5 L a day of hydrogen water or plain water for 4 weeks. The hydrogen group showed lower markers of inflammation in blood cells and higher antioxidant capacity in people over 30.
  • Exercise review (Li, 2024): across 6 small studies, hydrogen improved antioxidant capacity but did not lower measured oxidative stress.
  • Metabolic syndrome (LeBaron, 2020): 24 weeks of high-concentration hydrogen water lowered some inflammation markers. See blood sugar and cholesterol.
Blue reagent drops being added to a vial of water next to a glass of bubbly water and a rack of blue test samples
Testing hydrogen levels.

How to read this

  • Lab results are strong; human results are mixed and small
  • "Antioxidant capacity" and "inflammation markers" are lab measures, not the same as feeling or getting better
  • Researchers now think hydrogen may work through cell signaling, not only as a direct antioxidant

Bottom line

There's a real scientific basis for studying hydrogen and oxidative stress, and some human trials show changes in lab markers. Whether those changes lead to meaningful health benefits isn't known yet.

Sources

  • Ohsawa I, et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nature Medicine, 2007.
  • Sim M, et al. Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double-blind, controlled trial. Scientific Reports, 2020.
  • Li Y, et al. Can molecular hydrogen supplementation reduce exercise-induced oxidative stress in healthy adults? A systematic review and meta-analysis. Frontiers in Nutrition, 2024. Read it
  • LeBaron TW, et al. The effects of 24-week, high-concentration hydrogen-rich water on body composition, blood lipid profiles and inflammation biomarkers in men and women with metabolic syndrome. Diabetes, Metabolic Syndrome and Obesity, 2020. Read it

Not medical advice. Hydrogen water is not intended to diagnose, treat, cure or prevent any disease. Talk with your doctor about any health condition or medication.

Try fresh hydrogen alkaline water in Albuquerque. Your first visit is free. Call (505) 498-4098 to claim it.

Common questions

Is hydrogen water an antioxidant?

Molecular hydrogen has antioxidant activity in lab studies. In people, effects on antioxidant measures have been modest.

Can it help arthritis?

There's no strong evidence. Talk with your doctor about arthritis treatment.

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